ELISA PRMT5 anti-

Quantity :50µg Clone Number: Aliases:72 kDa ICln binding protein antibody; 72 kDa ICln-binding protein antibody; ANM5_ antibody; Histone synthetic lethal 7; S. cerevisiae; homolog of antibody; Histone-arginine N-methyltransferase PRMT5 antibody; HMT1 hnRNP methyltransferase like 5 antibody; HOMOLOG OF; SKB1 antibody; HRMT1L5 antibody; IBP72 antibody; Jak-binding protein 1 antibody; JBP 1 antibody; JBP1 antibody; PRMT 5 antibody; PRMT5 antibody; Protein arginine methyltransferase 5 antibody; Protein arginine N methyltransferase 5 antibody; Protein arginine N methyltransferase 5 N terminally processed antibody; Protein arginine N-methyltransferase 5 antibody; S. POMBE antibody; S. POMBE HOMOLOG OF; SKB1 antibody; SHK1 KINASE BINDING PROTEIN 1 antibody; Shk1 kinase binding protein 1 homolog antibody; Shk1 kinase-binding protein 1 homolog antibody; Shk1 kinase/binding protein 1; S. pombe; homolog of antibody; SKB 1 antibody; SKB1 antibody; SKB1 homolog antibody; SKB1: SKB1 homolog (S. pombe) antibody; SKB1Hs antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14744 Immunogen:Recombinant Protein arginine N-methyltransferase 5 protein (297-534AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regµLate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regµLates cyclin E1 promoter activity and cellµLar proliferation. Methylates histone H2A and H4 \'Arg-3\' during germ cell development. Methylates histone H3 \'Arg-8\', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling throµgh the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR \'Tyr-1197\' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regµLates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regµLating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regµLating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PRMT5 Research Areas:Epigenetics and Nuclear Signaling