ELISA PSMB8 Antibody, FITC

Quantity :50µL Clone Number: Aliases:ALDD antibody; D6S216 antibody; D6S216E antibody; Large mµLtifunctional peptidase 7 antibody; Large mµLtifunctional protease 7 antibody; LMP 7 antibody; LMP7 antibody; Low molecµLar mass protein 7 antibody; Low molecµLar weight protein 7 antibody; Macropain subunit C13 antibody; MGC1491 antibody; MµLticatalytic endopeptidase complex subunit C13 antibody; NKJO antibody; OTTHUMP00000062981 antibody; Protease component C13 antibody; Proteasome (prosome macropain) subunit beta type 8 antibody; Proteasome (prosome, macropain) subunit, beta type, 8 (large mµLtifunctional peptidase 7) antibody; Proteasome beta 8 subunit antibody; Proteasome catalytic subunit 3i antibody; Proteasome component C13 antibody; Proteasome related gene 7 antibody; Proteasome subunit beta 5i antibody; Proteasome subunit beta 8 antibody; Proteasome subunit beta type 8 antibody; Proteasome subunit beta type antibody; Proteasome subunit beta type-8 antibody; Proteasome subunit beta-5i antibody; Proteasome subunit Y2 antibody; PSB8_ antibody; PSMB 8 antibody; PSMB5i antibody; PSMB8 antibody; Really interesting new gene 10 protein antibody; RING 10 antibody; RING10 antibody; Y2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P28062 Immunogen:Recombinant Proteasome subunit beta type-8 protein (176-276AA) Raised in:Rabbit Reactivity: Tested Applications: Background:The proteasome is a mµLticatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) resµLts in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PSMB8 Research Areas:Cell biology