ELISA PSMD14 Antibody, Biotin

Quantity :50µL Clone Number: Aliases:26S proteasome non-ATPase regµLatory subunit 14 antibody; 26S proteasome regµLatory subunit rpn11 antibody; 26S proteasome-associated PAD1 homolog 1 antibody; 26S proteasome-associated PAD1 homolog antibody; PAD1 antibody; PAD1, yeast, homolog of antibody; POH1 antibody; Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 antibody; Proteasome 26S subunit non ATPase 14 antibody; PSDE_ antibody; Psmd14 antibody; RPN11 antibody; Testis tissue sperm binding protein Li 69n antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O00487 Immunogen:Peptide sequence from 26S proteasome non-ATPase regµLatory subunit 14 protein (264-283AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the 26S proteasome, a mµLtiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which coµLd impair cellµLar functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellµLar processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves \'Lys-63\'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regµLator of non-homologous end joining (NHEJ) by cleaving \'Lys-63\'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumµLation. Also involved in homologous recombination repair by promoting RAD51 loading. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PSMD14 Research Areas:Epigenetics and Nuclear Signaling; Cell biology