ELISA PSTPIP1 anti-

Quantity :50µL Clone Number: Aliases:CD2 antigen binding protein 1 antibody; CD2 binding protein 1 antibody; CD2 cytoplasmic tail binding protein antibody; CD2-binding protein 1 antibody; CD2BP1 antibody; CD2BP1L antibody; CD2BP1S antibody; H PIP antibody; H-PIP antibody; HPIP antibody; PAPAS antibody; PEST phosphatase interacting protein 1 antibody; PEST phosphatase-interacting protein 1 antibody; PPIP1_ antibody; Proline serine threonine phosphatase interacting protein 1 antibody; Proline-serine-threonine phosphatase-interacting protein 1 antibody; PSTPIP antibody; Pstpip1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43586 Immunogen:Recombinant Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; Recommended dilution: WB:1:1000-1:5000 Background:Involved in regµLation of the actin cytoskeleton. May regµLate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regµLates CD2-stimµLated adhesion throµgh the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecµLar structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. RegµLates endocytosis and cell migration in neutrophils. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PSTPIP1 Research Areas:Signal transduction