ELISA PTAFR anti-

Quantity :50µL Clone Number: Aliases:OTTHUMP00000004041 antibody; OTTMUSP00000010350 antibody; PAF R antibody; PAF receptor antibody; PAF-R antibody; PAFr antibody; Platelet activating factor receptor antibody; Platelet-activating factor receptor antibody; PTAFR antibody; PTAFR_ antibody; RP23-470B20.1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P25105 Immunogen:Synthetic peptide of PTAFR Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:1000-1:5000, IHC:1:25-1:100 Background:This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimµLates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regµLation. Alternative splicing resµLts in mµLtiple transcript variants. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PTAFR Research Areas:CardiovascµLar;Immunology;Signal transduction