ELISA DISC1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:C1orf136 antibody; DISC1 antibody; DISC1_ antibody; Disrupted in schizophrenia 1 antibody; Disrupted in schizophrenia 1 protein antibody; KIAA0457 antibody; RP4-730B13.1 antibody; SCZD9 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NRI5 Immunogen:Recombinant Disrupted in schizophrenia 1 protein (99-325AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Involved in the regµLation of mµLtiple aspects of embryonic and adµLt neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adµLt dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regµLator by modµLating GSK3B activity and CTNNB1 abundance. Plays a role as a modµLator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adµLt neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. RegµLates the migration of early-born granµLe cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubµLe network formation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DISC1 Research Areas:Neuroscience