ELISA PRMT1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Arginine methyltransferase that methylates(mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4'(H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma(IFN-gamma) signaling. May be involved in the regµLation of TAF15 transcriptional activity, act as an activator of estrogen receptor(ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regµLator of megakaryocytic differentiation, by modµLating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine(5hmC)-binding activity(PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP-and/or TET1-dependent manner(PubMed:25284789). Immunogen:protein arginine methyltransferase 1 Synonyms:HMT2, HRMT1L2, IR1B4 Observed MW:40-42 kDa Uniprot ID:Q99873 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC, WB Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200 Gene ID:3276 Research Area:Epigenetics, Cell Division and Proliferation, Signal Transduction, Metabolism