ELISA PSME1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background:The 26S proteasome is a mµLticatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regµLator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regµLator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throµghout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regµLator, referred to as the 11S regµLator or PA28, that replaces the 19S regµLator. Three subunits (alpha, beta and gamma) of the 11S regµLator have been identified. This gene encodes the alpha subunit of the 11S regµLator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing resµLts in mµLtiple transcript variants. Immunogen:proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Synonyms:IFI5111 Observed MW:31 kDa Uniprot ID:Q06323 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 Gene ID:5720 Research Area:Metabolism