ELISA PSME3 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Subunit of the 11S REG-gamma(also called PA28-gamma) proteasome regµLator, a doµghnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring(PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination-and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumµLation and resµLting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regµLation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition(PubMed:25361978). Immunogen:proteasome(prosome, macropain) activator subunit 3(PA28 gamma; Ki) Synonyms: Observed MW:30 kDa Uniprot ID:P61289 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IF, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200 Gene ID:10197 Research Area:Cancer, Metabolism